Prime

Prime Prime is a fully-integrated protein structure prediction solution that incorporates homology modeling and fold recognition into a single solution. Prime includes an intuitive step-by-step interface that takes users through the workflow of structure prediction by supplying helpful default settings for each stage of the process.

 

Prime provides the tools for three main tasks: homology modeling, structure refinement, and binding energy estimation, all of which are accessible from the Maestro interface.

 

The Prime panels were designed to accommodate both novice and expert users, while the underlying programs were designed to produce superior results in a variety of applications, including:

• Refinement of active sites

• Induced-fit optimization

• Structure-based functional annotation

• Generation of alternate loop conformations

• Ligand binding energies

• Protein structural alignment

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