Installing Prime Third-Party Databases on a Mac
Prime requires access to the PDB and BLAST databases. If these databases are not installed locally, you can use web access to send queries and retrieve the results. If you want to use a local installation instead (for security reasons, for example), use the following instructions.
| 1. | Open a terminal window. |
| 2. | Set the SCHRODINGER_THIRDPARTY environment variable to a suitable location that is not inside your software distribution, e.g. |
export SCHRODINGER_THIRDPARTY=/opt/schrodinger/thirdparty
This choice ensures that the database is not installed inside your software installation, as it would be removed when you uninstalled the software.
Indexing these databases causes severe performance issues, so you should turn off indexing of this directory before starting the installation.
| 3. | Open System Preferences and click on Spotlight. |
| 4. | In the Privacy tab, add the location that you chose for the third-party software above. |
Now you can perform the installation.
| 5. | In the terminal window, run the following commands: |
$SCHRODINGER/utilities/update_BLASTDB
$SCHRODINGER/utilities/rsync_pdb
Due to the size of these databases, the commands may take some time to run.
If you want to use PSIPRED, you must compile it in a terminal window using the Linux instructions in Installing Prime Third-Party Software and Databases on Linux. To do so, you must have XCode installed, including the command-line tools (Preferences → Downloads → Command-Line Tools in XCode, and click Install). The command-line tools require an Apple Developer account.