auto_reaction_workflow.py Command Help

Command: $SCHRODINGER/run auto_reaction_workflow.py

usage: $SCHRODINGER/run auto_reaction_workflow.py [-h]
                                                  [-novel_rxnwf_file NOVEL_RXNWF_FILE]
                                                  [-novel_sdf_file NOVEL_SDF_FILE]
                                                  [-only_sdf_conversion]
                                                  -reference_rxnwf_file
                                                  REFERENCE_RXNWF_FILE
                                                  [-only_rxnwf_files]
                                                  [-require_identical_bonds]
                                                  [-mass_conserved]
                                                  [-out_rep {centroid,eta}]
                                                  [-rgroup_file FILE_NAME INDEX FILE_NAME INDEX]
                                                  [-site [KEEP_ATOM_INDEX REPLACE_ATOM_INDEX INDEX [STRUCTURE_INDEX]
                                                  [NOVEL or REFERENCE] ...]]
                                                  [-force_hetero_substitution]
                                                  [-dup_smiles]
                                                  [-csearch_engine {Macromodel,Crest}]
                                                  [-forcefield FORCE_FIELD]
                                                  [-skip_eta_rotamers]
                                                  [-metal_index METAL_INDEX]
                                                  [-com_fn COM_FN]
                                                  [-seed SEED]
                                                  [-n_conformers N_CONFORMERS]
                                                  [-pp_rel_energy_thresh PP_REL_ENERGY_THRESH]
                                                  [-return_csearch_files]
                                                  [-qm_selection]
                                                  [-n_rotamers N_ROTAMERS]
                                                  [-refined_energy]
                                                  [-refined_energy_jaguar_keywords [<key_1>=<value_1> [<key_2>=<value_2> ...]]]
                                                  [-refined_energy_thermo_correction]
                                                  [-refined_energy_thermo_correction_jaguar_keywords [<key_1>=<value_1> [<key_2>=<value_2> ...]]]
                                                  [-refined_energy_n_conformers REFINED_ENERGY_N_CONFORMERS]
                                                  [-refined_energy_pp_rel_energy_thresh REFINED_ENERGY_PP_REL_ENERGY_THRESH]
                                                  [-dedup_geom_eps DEDUP_GEOM_EPS]
                                                  [-mopac] [-xtb] [-uma]
                                                  [-jaguar_keywords [<key_1>=<value_1> [<key_2>=<value_2> ...]]]
                                                  [-ts_jaguar_keywords [<key_1>=<value_1> [<key_2>=<value_2> ...]]]
                                                  [-temp_start TEMP_START]
                                                  [-temp_step TEMP_STEP]
                                                  [-temp_n TEMP_N]
                                                  [-press_start PRESS_START]
                                                  [-press_step PRESS_STEP]
                                                  [-press_n PRESS_N]
                                                  [-temp_press_props_file TEMP_PRESS_PROPS_FILE]
                                                  [-return_jaguar_files]
                                                  [-solvation_entropy]
                                                  [-solvation_entropy_solvent {1,1,1-trichloroethane,1,1,2-trichloroethane,1,2,4-trimethylbenzene,1,2-dibromoethane,1,2-dichloroethane,1,2-ethanediol,1,4-dioxane,1-bromo-2-methylpropane,1-bromooctane,1-bromopentane,1-bromopropane,1-butanol,1-chlorohexane,1-chloropentane,1-chloropropane,1-decanol,1-fluorooctane,1-heptanol,1-hexanol,1-hexene,1-hexyne,1-iodobutane,1-iodohexadecane,1-iodopentane,1-iodopropane,1-nitropropane,1-nonanol,1-octanol,1-pentanol,1-pentene,1-pentyne,1-propanol,2,2,2-trifluoroethanol,2,2,4-trimethylpentane,2,4-dimethylpentane,2,4-dimethylpyridine,2,6-dimethylpyridine,2-bromopropane,2-butanol,2-chlorobutane,2-heptanone,2-hexanone,2-methoxyethanol,2-methyl-1-propanol,2-methyl-2-propanol,2-methylpentane,2-methylpyridine,2-methyltetrahydrofuran,2-nitropropane,2-octanone,2-pentanone,2-propanol,2-propen-1-ol,3-methylpyridine,3-pentanone,4-heptanone,4-methyl-2-pentanone,4-methylpyridine,5-nonanone,DMSO,E-1,2-dichloroethene,E-2-pentene,N-methylaniline,N-methylformamide,Z-1,2-dichloroethene,a-chlorotoluene,acetic acid,acetic_acid,acetone,acetonitrile,acetophenone,amyl acetate,aniline,anisole,benzaldehyde,benzene,benzonitrile,benzyl alcohol,benzyl_alcohol,bromobenzene,bromoethane,bromoform,butanal,butanenitrile,butanoic acid,butanoic_acid,butanone,butyl ethanoate,butyl_ethanoate,butylamine,carbon disulfide,carbon tetrachloride,carbon_disulfide,carbon_tet,chlorobenzene,chloroform,cis-1,2-dimethylcyclohexane,cis-decalin,cyclohexane,cyclohexanone,cyclopentane,cyclopentanol,cyclopentanone,decalin,decalin_(mixture),dibromomethane,dibutyl_ether,dibutylether,dichloroethane,dichloromethane,diethyl_ether,diethyl_sulfide,diethylamine,diethylether,diethylsulfide,diiodomethane,diisopropyl ether,diisopropyl_ether,dimethyl disulfide,dimethyl_disulfide,dimethylacetamide,dimethylformamide,dioxane,diphenyl ether,diphenylether,dipropylamine,dma,dmso,e-1,2-dichloroethene,e-2-pentene,ethanethiol,ethanol,ethyl acetate,ethyl methanoate,ethyl phenyl ether,ethyl_ethanoate,ethyl_methanoate,ethyl_phenyl_ether,ethylbenzene,fluorobenzene,formamide,formic acid,formic_acid,hexanoic acid,hexanoic_acid,iodobenzene,iodoethane,iodomethane,iso-butanol,isopropylbenzene,m-cresol,m-xylene,mesitylene,methanol,methyl acetate,methyl benzoate,methyl butanoate,methyl formate,methyl propionate,methyl_benzoate,methyl_butanoate,methyl_ethanoate,methyl_methanoate,methyl_propanoate,methylcyclohexane,n-butylbenzene,n-decane,n-dodecane,n-heptane,n-hexadecane,n-hexane,n-methylaniline,n-methylformamide_(mixture),n-nonane,n-octane,n-pentadecane,n-pentane,n-undecane,nitrobenzene,nitroethane,nitromethane,o-chlorotoluene,o-cresol,o-dichlorobenzene,o-nitrotoluene,o-xylene,p-isopropyltoluene,p-xylene,pentanal,pentanoic acid,pentanoic_acid,pentyl_ethanoate,pentylamine,perfluorobenzene,propanal,propanenitrile,propanoic acid,propanoic_acid,propyl acetate,propyl_ethanoate,propylamine,pyridine,pyrrolidine,sec-butylbenzene,tert-butanol,tert-butylbenzene,tetrachloroethene,tetrahydrofuran,tetrahydrothiophene-S,S-dioxide,tetrahydrothiophene_dioxide,tetralin,thiophene,thiophenol,toluene,trans-decalin,tributyl phosphate,tributylphosphate,trichloroethene,triethylamine,water,xylene_(mixture),z-1,2-dichloroethene}]
                                                  [-anharm]
                                                  [-return_anharm_files]
                                                  [-anharm_max_freq WAVENUMBERS]
                                                  [-anharm_factor_data START STEP N_POINTS START STEP N_POINTS START STEP N_POINTS]
                                                  [-rate_constants]
                                                  [-return_rate_constant_files]
                                                  [-custom_rate_constants]
                                                  [-wigner_tunnel_corr]
                                                  [-extra_stages_file EXTRA_STAGES_FILE]
                                                  [-max_i_freq WAVENUMBERS]
                                                  [-descriptors]
                                                  [-energy_prop PROPERTY_NAME]
                                                  [-lowest]
                                                  [-return_descriptor_files]
                                                  [-HOST <hostname>] [-SAVE]
                                                  [-JOBNAME JOBNAME]
                                                  [-n_rxnwf_subjobs N_RXNWF_SUBJOBS]
                                                  [-n_jmswf_subjobs N_JMSWF_SUBJOBS]
                                                  [-TPP TPP]
                                                  [-jmswf_host JMSWF_HOST]
                                                  [-max_retries MAX_RETRIES]

Driver for automatic reaction workflow. Copyright Schrodinger, LLC. All rights
reserved.

options:
  -h, -help             Show this help message and exit.
  -novel_rxnwf_file NOVEL_RXNWF_FILE
                        Specify a reaction workflow Maestro file containing
                        the single novel structure. This structure must
                        contain atoms marked with the
                        "b_matsci_Reaction_Workflow_Keep_Atom" property which
                        specify those atoms to be kept when swapping fragments
                        with the structures in the given reference reaction
                        workflow file (see option "-reference_rxnwf_file").
                        This structure must also contain atoms marked with the
                        "i_matsci_Reaction_Workflow_Superposition_Atom"
                        property which specify how to superpose it onto those
                        reference structures. (default: None)
  -novel_sdf_file NOVEL_SDF_FILE
                        As an alternative to providing input using
                        "-novel_rxnwf_file" specify a 2D *sdf file containing
                        the single novel structure. This file must be marked
                        up with the relevant reaction workflow arguments. Also
                        see option "-only_sdf_conversion". (default: None)
  -only_sdf_conversion  Use this option to exit after converting a 2D *sdf
                        file specified with "-novel_sdf_file" to a 3D reaction
                        workflow *mae file. (default: False)
  -reference_rxnwf_file REFERENCE_RXNWF_FILE
                        Specify a reaction workflow Maestro file containing
                        the reference structures. Those structures that are
                        swapping fragments with a given novel structure (see
                        option "-novel_rxnwf_file" or "-novel_sdf_file") must
                        contain atoms marked with the
                        "b_matsci_Reaction_Workflow_Keep_Atom" property which
                        specify those atoms to be kept when swapping
                        fragments. These structures must also contain atoms
                        marked with the
                        "i_matsci_Reaction_Workflow_Superposition_Atom"
                        property which specify how to superpose them onto a
                        novel structure. (default: None)
  -only_rxnwf_files     Use this option to exit after creating all reaction
                        workflow files. These files include any swaps with a
                        given novel structure and any R-group enumerations.
                        (default: False)
  -require_identical_bonds
                        This requires that bonds being created when swapping
                        novel and reference catalysts must exist in both
                        structures and be of the same bond order. When not
                        used all bonds being cut in the novel structure will
                        be created provided that there is a reference keep
                        atom corresponding to the novel replace atom.
                        (default: False)
  -mass_conserved       Use this option to early exit if mass is not conserved
                        in the given reference reaction workflow input file.
                        (default: False)
  -out_rep {centroid,eta}
                        Force a specific output representation. If not
                        provided it will be the opposite of the input
                        representation. (default: None)

Enumerate Reaction Workflow:
  -rgroup_file FILE_NAME INDEX FILE_NAME INDEX
                        Specify any R-group files using this option. Define
                        each file using (1) the file name and (2) an
                        enumeration index which maps the file to sites (see
                        "-site" below). Files should be Maestro files
                        containing R-groups prepared with the R-Group Creator
                        GUI. This option may be specified multiple times. For
                        example, "-rgroup_file alkyl.mae 1 -rgroup_file
                        aryl.mae 2 -rgroup_file alkyl.mae 3" means that for
                        sites with enumeration indices 1 and 3 the alkyl.mae
                        file will be used while for sites with enumeration
                        index 2 the aryl.mae file will be used. Note that when
                        multiple sites use the same file there is an
                        additional option "-force_hetero_substitution" which
                        controls whether to return only the hetero-substituted
                        results or both hetero- and homo-substituted results.
                        (default: [])
  -site [KEEP_ATOM_INDEX REPLACE_ATOM_INDEX INDEX [STRUCTURE_INDEX] [NOVEL or REFERENCE] ...]
                        Specify any enumeration sites using this option.
                        Define each site using three integers, (1) an atom
                        index which specifies the direction of the
                        substitution relative to (2), (2) an atom index which
                        specifies the substitution site, and (3) an
                        enumeration index which maps the site to an R-group
                        file (see "-rgroup_file" above). Atom indices for (1)
                        (a "from" atom) and (2) (a "to" atom) should be bonded
                        with a single acyclic bond and on substitution are
                        kept and replaced, respectively. This option may be
                        specified multiple times. For example, "-site 4 3 1
                        -site 23 17 2 -site 9 10 1" means that atoms 3 and 10
                        will be substituted with some R-group (indexed with
                        the 1 mapping to some file) such that atoms 4 and 9
                        respectively are kept, while atom 17 will be
                        substituted with a potentially different R-group
                        (indexed with the 2 potentially mapping to a different
                        file) such that atom 23 is kept. An optional fourth
                        integer item could be specified that indexes in a
                        given input reaction workflow file the structure to
                        which this site applies to (see the following optional
                        fifth string item). If not provided then it is assumed
                        to be for the single novel structure. An optional
                        fifth string item could be specified to indicate
                        whether the site applies to the "novel" structure or
                        "reference" structures. If not provided then it is
                        assumed to be for the novel structure. (default: [])
  -force_hetero_substitution
                        By default when sites with different enumeration
                        indices use the same R-group file both hetero- and
                        homo-enumerated results are returned. Use this option
                        to return only hetero-enumerated results in such
                        cases. (default: False)
  -dup_smiles           When doing multi-site R-group enumeration all
                        possiblepermutations of R-group sites onto structure
                        sites are considered and by default the resulting
                        structures are deduplicated using SMILES. Use this
                        option to instead skip the SMILES deduplication and
                        return all structures. (default: False)

Conformational search and selection:
  -csearch_engine {Macromodel,Crest}
                        The engine to use for the conformational search.
                        (default: Macromodel)
  -forcefield FORCE_FIELD
                        Force field to use. Valid force fields are OPLS_2005
                        and S-OPLS (default: S-OPLS)
  -skip_eta_rotamers    Specify that eta rotamers generation will be skipped.
                        (default: False)
  -metal_index METAL_INDEX
                        Index of the metal atom around which to generate eta-
                        rotamers. If not provided and the structure has a
                        single metal atom then that index will automatically
                        be used. (default: None)
  -com_fn COM_FN        Use the settings in this example MacroModel .com file
                        for the conformational search rather than the default
                        settings. (default: None)
  -seed SEED            Specify a seed for the random number generator used
                        for any conformational searches. (default: 1234)
  -n_conformers N_CONFORMERS
                        Specify the number of conformers to search for.
                        (default: 5)
  -pp_rel_energy_thresh PP_REL_ENERGY_THRESH
                        If given, specifies to instead search for all
                        conformers with relative energies <= this value in
                        kJ/mol. (default: None)
  -return_csearch_files
                        Use this option to return all output files from any
                        conformational search subjobs. (default: False)
  -qm_selection         Use this option to select conformers from quantum
                        energies rather than from classical energies.
                        (default: False)
  -n_rotamers N_ROTAMERS
                        Specifies the number of guess rotamers for eta-bound
                        ligands prior to MacroModel conformational search. If
                        not given then it will be twice the number of ring
                        atoms in the haptic ring. (default: None)
  -refined_energy       Specifies a second stage of conformer selection using
                        refined energies. (default: False)
  -refined_energy_jaguar_keywords [<key_1>=<value_1> [<key_2>=<value_2> ...]]
                        Specify Jaguar &gen section key-value pairs for single
                        point energy calculations used for refinement. Each
                        key-value pair should be separated from the next by
                        whitespace and each should be represented in terms of
                        a '<key>=<value>' pair. (default: ('dftname=M06-L',
                        'basis=LACV3P++**'))
  -refined_energy_thermo_correction
                        Include thermochemical corrections in the refined
                        energies. (default: False)
  -refined_energy_thermo_correction_jaguar_keywords [<key_1>=<value_1> [<key_2>=<value_2> ...]]
                        Specify Jaguar &gen section key-value pairs for
                        optimized energy calculations used for the
                        thermochemical corrections to the refinement. Each
                        key-value pair should be separated from the next by
                        whitespace and each should be represented in terms of
                        a '<key>=<value>' pair. (default: ('xtb=1',))
  -refined_energy_n_conformers REFINED_ENERGY_N_CONFORMERS
                        The number of conformers to select after refinement.
                        (default: 5)
  -refined_energy_pp_rel_energy_thresh REFINED_ENERGY_PP_REL_ENERGY_THRESH
                        If given, specifies to instead select all conformers
                        after refinement with relative energies <= this value
                        in kJ/mol. (default: None)

Reaction Workflow Driver:
  -dedup_geom_eps DEDUP_GEOM_EPS
                        Reduce the number of calculations by deduplicating the
                        input structures based on geometry, using this
                        threshold in Ang., and only calculating the
                        representatives. A value of zero means no
                        deduplicating. (default: 0.25)
  -mopac                Use this option to run Mopac geometry optimizations
                        and frequencies on each conformer. (default: False)
  -xtb                  Use this option to run xTB geometry optimizations on
                        each conformer. (default: False)
  -uma                  Use this option to run UMA geometry optimizations on
                        each conformer. (default: False)
  -jaguar_keywords [<key_1>=<value_1> [<key_2>=<value_2> ...]]
                        Specify Jaguar &gen section key-value pairs. Each key-
                        value pair should be separated from the next by
                        whitespace and each should be represented in terms of
                        a '<key>=<value>' pair. (default: ['dftname=B3LYP',
                        'basis=LACVP**', 'maxitg=200'])
  -ts_jaguar_keywords [<key_1>=<value_1> [<key_2>=<value_2> ...]]
                        Specify Jaguar &gen section key-value pairs for
                        transition state searches. Each key-value pair should
                        be separated from the next by whitespace and each
                        should be represented in terms of a '<key>=<value>'
                        pair. If not given then the Jaguar keywords given
                        using the flag -jaguar_keywords will be used for
                        transition state searches. (default: None)
  -temp_start TEMP_START
                        Specify the starting temperature (K) at which
                        thermochemical properties will be calculated.
                        (default: 298.15)
  -temp_step TEMP_STEP  Specify the step size of the temperature (K) (see
                        option -temp_start). (default: 10.0)
  -temp_n TEMP_N        Specify the number of temperatures (see options
                        -temp_start and -temp_step). (default: 1)
  -press_start PRESS_START
                        Specify the starting pressure (atm) at which
                        thermochemical properties will be calculated.
                        (default: 1.0)
  -press_step PRESS_STEP
                        Specify the step size of the pressure (atm) (see
                        option -press_start). (default: 1.0)
  -press_n PRESS_N      Specify the number of pressures (see options
                        -press_start and -press_step). (default: 1)
  -temp_press_props_file TEMP_PRESS_PROPS_FILE
                        Specify a csv file of temperature and/or pressure
                        dependent properties. Temperature and/or pressure
                        values therein must be among those generated using the
                        start, step, and number of points flags: -temp_start,
                        -temp_step, -temp_n, -press_start, -press_step, and
                        -press_n. The columns of the csv must be named
                        temperature_K, pressure_atm, and
                        solvent_density_g_cm3. (default: None)
  -return_jaguar_files  Use this option to return all output files from any
                        Jaguar subjobs. (default: False)
  -solvation_entropy    Use this option to correct thermochemical properties,
                        and rate constants, by accounting for the entropy of
                        solvation using the model proposed by Garza. (default:
                        False)
  -solvation_entropy_solvent {1,1,1-trichloroethane,1,1,2-trichloroethane,1,2,4-trimethylbenzene,1,2-dibromoethane,1,2-dichloroethane,1,2-ethanediol,1,4-dioxane,1-bromo-2-methylpropane,1-bromooctane,1-bromopentane,1-bromopropane,1-butanol,1-chlorohexane,1-chloropentane,1-chloropropane,1-decanol,1-fluorooctane,1-heptanol,1-hexanol,1-hexene,1-hexyne,1-iodobutane,1-iodohexadecane,1-iodopentane,1-iodopropane,1-nitropropane,1-nonanol,1-octanol,1-pentanol,1-pentene,1-pentyne,1-propanol,2,2,2-trifluoroethanol,2,2,4-trimethylpentane,2,4-dimethylpentane,2,4-dimethylpyridine,2,6-dimethylpyridine,2-bromopropane,2-butanol,2-chlorobutane,2-heptanone,2-hexanone,2-methoxyethanol,2-methyl-1-propanol,2-methyl-2-propanol,2-methylpentane,2-methylpyridine,2-methyltetrahydrofuran,2-nitropropane,2-octanone,2-pentanone,2-propanol,2-propen-1-ol,3-methylpyridine,3-pentanone,4-heptanone,4-methyl-2-pentanone,4-methylpyridine,5-nonanone,DMSO,E-1,2-dichloroethene,E-2-pentene,N-methylaniline,N-methylformamide,Z-1,2-dichloroethene,a-chlorotoluene,acetic acid,acetic_acid,acetone,acetonitrile,acetophenone,amyl acetate,aniline,anisole,benzaldehyde,benzene,benzonitrile,benzyl alcohol,benzyl_alcohol,bromobenzene,bromoethane,bromoform,butanal,butanenitrile,butanoic acid,butanoic_acid,butanone,butyl ethanoate,butyl_ethanoate,butylamine,carbon disulfide,carbon tetrachloride,carbon_disulfide,carbon_tet,chlorobenzene,chloroform,cis-1,2-dimethylcyclohexane,cis-decalin,cyclohexane,cyclohexanone,cyclopentane,cyclopentanol,cyclopentanone,decalin,decalin_(mixture),dibromomethane,dibutyl_ether,dibutylether,dichloroethane,dichloromethane,diethyl_ether,diethyl_sulfide,diethylamine,diethylether,diethylsulfide,diiodomethane,diisopropyl ether,diisopropyl_ether,dimethyl disulfide,dimethyl_disulfide,dimethylacetamide,dimethylformamide,dioxane,diphenyl ether,diphenylether,dipropylamine,dma,dmso,e-1,2-dichloroethene,e-2-pentene,ethanethiol,ethanol,ethyl acetate,ethyl methanoate,ethyl phenyl ether,ethyl_ethanoate,ethyl_methanoate,ethyl_phenyl_ether,ethylbenzene,fluorobenzene,formamide,formic acid,formic_acid,hexanoic acid,hexanoic_acid,iodobenzene,iodoethane,iodomethane,iso-butanol,isopropylbenzene,m-cresol,m-xylene,mesitylene,methanol,methyl acetate,methyl benzoate,methyl butanoate,methyl formate,methyl propionate,methyl_benzoate,methyl_butanoate,methyl_ethanoate,methyl_methanoate,methyl_propanoate,methylcyclohexane,n-butylbenzene,n-decane,n-dodecane,n-heptane,n-hexadecane,n-hexane,n-methylaniline,n-methylformamide_(mixture),n-nonane,n-octane,n-pentadecane,n-pentane,n-undecane,nitrobenzene,nitroethane,nitromethane,o-chlorotoluene,o-cresol,o-dichlorobenzene,o-nitrotoluene,o-xylene,p-isopropyltoluene,p-xylene,pentanal,pentanoic acid,pentanoic_acid,pentyl_ethanoate,pentylamine,perfluorobenzene,propanal,propanenitrile,propanoic acid,propanoic_acid,propyl acetate,propyl_ethanoate,propylamine,pyridine,pyrrolidine,sec-butylbenzene,tert-butanol,tert-butylbenzene,tetrachloroethene,tetrahydrofuran,tetrahydrothiophene-S,S-dioxide,tetrahydrothiophene_dioxide,tetralin,thiophene,thiophenol,toluene,trans-decalin,tributyl phosphate,tributylphosphate,trichloroethene,triethylamine,water,xylene_(mixture),z-1,2-dichloroethene}
                        Specify the solvent to use when calculating the
                        solvation entropy. The choice of solvent defines
                        various parameters needed to calculate the solvation
                        entropy. Supported solvents are those available in
                        Jaguar. (default: water)
  -anharm               Use this option to run a workflow that corrects
                        thermochemical properties, and potentially rate
                        constants, by accounting for anharmonicities in the
                        low frequency normal modes. (default: False)
  -return_anharm_files  Use this option to return all output files from any
                        anharmonic workflow subjobs. (default: False)
  -anharm_max_freq WAVENUMBERS
                        Normal modes with harmonic frequencies less than this
                        value in wavenumbers (cm^-1) will be treated
                        anharmonically. (default: 300)
  -anharm_factor_data START STEP N_POINTS START STEP N_POINTS START STEP N_POINTS
                        Unitless data for factors that multiply normal mode
                        displacements. Specify whitespace separated values for
                        the start, step, and number of points, which should be
                        for the positive direction only. (default: [0.5, 1.0,
                        4])
  -rate_constants       Use this option to report rate constant(s) for the
                        rate determining step of the reaction using canonical
                        transition state theory. (default: False)
  -return_rate_constant_files
                        Use this option to return all output files from any
                        rate constant subjobs. (default: False)
  -custom_rate_constants
                        When computing rate constants with -rate_constants use
                        custom equations. (default: False)
  -wigner_tunnel_corr   Use this option to include the Wigner tunneling
                        correction when computing rate constant(s). (default:
                        False)
  -extra_stages_file EXTRA_STAGES_FILE
                        Specify extra stages for a Jaguar Multistage Workflow
                        subjob that will be performed using all of the output
                        structures from the reaction workflow. The first of
                        these extra stages will be skipped so that analysis
                        can potentially be the first extra stage. (default:
                        None)
  -max_i_freq WAVENUMBERS
                        Check the number of imaginary frequencies using this
                        tolerance in wavenumbers (cm^-1). (default: 0)

Descriptors:
  -descriptors          Use this option to report cheminformatics descriptors
                        for all output reaction workflow files. (default:
                        False)
  -energy_prop PROPERTY_NAME
                        Specify the energy property to use for Boltzmann
                        averaging. If temperature dependent then the
                        temperature must be reported in K and this temperature
                        will be used for averaging. Otherwise the input
                        temperatures in K will be used. This energy property
                        key must be of known units. Valid keys are for example
                        r_j_Gas_Phase_Energy,
                        r_j_Total_Free_Energy_(au)_298.15K_1.00E+00atm,
                        r_matsci_my_energy_(kcal/mol), etc. (default: None)
  -lowest               Specify whether to return the lowest energy conformer
                        instead of averaging properties over conformers.
                        (default: False)
  -return_descriptor_files
                        Use this option to return all output files from any
                        cheminformatics descriptor subjobs. (default: False)

Job Control Options:
  -HOST <hostname>      Run job remotely on the indicated host entry.
                        (default: localhost)
  -SAVE                 Return zip archive of job directory at job completion.
                        (default: False)
  -JOBNAME JOBNAME      Provide an explicit name for the job. (default: None)
  -n_rxnwf_subjobs N_RXNWF_SUBJOBS
                        Specify the maximum number of simultaneous reaction
                        workflow subjobs. (default: 1)
  -n_jmswf_subjobs N_JMSWF_SUBJOBS
                        Specify the maximum number of simultaneous Jaguar
                        multistage workflow subjobs. (default: 1)
  -TPP TPP              Specify the number of threads to use for parallelizing
                        any Jaguar subjobs. MacroModel conformational search
                        subjobs use a value of 1. (default: 1)
  -jmswf_host JMSWF_HOST
                        Specify the host to use for any Jaguar Multistage
                        Workflow subjobs. The driver host is specified using
                        -HOST. If -jmswf_host is not specified then the value
                        for -HOST is used. If -HOST is not specified then
                        localhost is used for both. (default: None)
  -max_retries MAX_RETRIES
                        Maximum number of times to try relaunching subjobs.
                        (default: 0)