λD Advanced Options Dialog Box

Set simulation options for FEP calculations with λD.

To open this dialog box, choose Advanced Options from the Settings button menu in the FEP Protein Mutation Panel.

Constant pH Advanced Options Dialog Box Features

Replicas text box

Set the number of replicas.

Simulation Parameters section

Set parameters for the MD simulations.

Simulation time text box

Specify the desired simulation time in ps. Longer simulation times can improve the accuracy of the results, at the expense of longer computation time.

Random seed text box

Set the seed for random number generation. This is used, for example, to randomize velocities. Setting the seed ensures that the same random numbers are generated for each simulation, which allows you to reproduce the simulation.

Reset button

Reset the panel to its default settings.