Identify Family Features Dialog Box

Select and compute family features for specified sequences in order to generate annotations.

To open this dialog box, choose Other Tasks → Identify Family Features in the Multiple Sequence Viewer/Editor Panel, or click Calculate Features in the Calculated Attributes tab of the Annotations Pane.

  • Features
  • Additional Resources

Identify Family Features Dialog Box Features

Domains option

Select to predict the arrangement of domains.

Pfam Family Classification option

Find globally conserved residues by running HMMER on the Pfam database. A Hidden Markov Model (HMM) is generated from a multiple sequence alignment and used to identify the family of the reference and provide information about which residues are conserved in the consensus sequence.

Antibody Regions menu

Select to choose the numbering scheme to use for the antibody residues. The choices are Chothia (J. Mol. Biol. 1987, 196, 901), Enhanced Chothia (http://www.bioinf.org.uk/abs/#martinnum), Kabat (J. Exp. Med. 1970, 132, 211), IMGT (Nucl. Acids Res. 1999, 27, 209), and AHo (J. Mol. Biol. 2001, 309, 657). This numbering scheme is only in effect when the Antibody CDRs annotation is turned on. When you export the antibody to a file, it is exported with the selected numbering scheme.

T-Cell Receptor Regions option and menu

Select to compute T-Cell Receptor (TCR) Regions values. From the menu, you can select IMGT or AHo numbering schemes. Note: Attempting to find antibody regions on a TCR with a non-supported TCR numbering scheme will result in a warning message.

GPCR Features option

Select to compute GPCR features.

Kinase Features option

Select to compute kinase features.

Kinase Binding Site Conservation option

Select to compute kinase conservation for the binding sites.

Identify features for selected sequences only button

This option will identify features for the selected sequences only, else all sequences will included.

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