Starting Maestro

Maestro has three profiles:

  • Maestro (life sciences and small molecules)

  • Maestro BioLuminate (biologics/proteins)

  • Materials Science Maestro (materials science)

When you download Schrödinger software, all profiles will download by default. You can deselect profiles you do not wish to download during the installation process if you prefer (see Profile Selection in the Installation Guide).

Schrödinger software is supported on Linux, Windows and Mac operating systems.

  • Windows
  • Mac
  • Linux

Double-click the icon on the desktop for the profile: Maestro, BioLuminate, Elements,or Materials.

You can also use Start → All Programs → Schrodinger-2026-1 → Maestro.

If you need to open a Maestro console window as well as start Maestro (e.g. for debugging or running command-line apps):

  1. Set the SCHRODINGER environment variable to point to your software installation (see Setting Environment Variables on Windows).

  2. Open a terminal app.

  3. Enter the following command:

    %SCHRODINGER%\run maestro_console.exe

Click the Maestro icon on the dock for the profile: Maestro, BioLuminate, Elements, or Materials.

If it is not on the dock, drag it there from the SchrodingerSuites2026-1 folder in your Applications folder, or start Maestro from that folder.

You can also start Maestro from the command line with the same commands as for Linux. If you need to open a console window, use the -console option.

Note that the working directory is the Mac default, regardless of where you issue the command, as the command runs the Maestro app rather than directly running the program.

  1. Open a terminal window.

  2. Set the SCHRODINGER environment variable to the Schrödinger software installation directory:

    csh/tcsh:

    setenv SCHRODINGER installation-path

    sh/bash/ksh:

    export SCHRODINGER=installation-path

  3. Enter the command for the profile you want to use:

    $SCHRODINGER/maestro [-profile profile]&

    where profile is one of Maestro, BioLuminate, Elements, or MaterialsScience. You can omit the -profile option for the Maestro profile.

    If you are running Maestro remotely, you should use the following commands:

    export VGL_GUI="none"
    vglrun $SCHRODINGER/maestro [-profile profile]&